ABSTRACT
Background: Dengue fever it one of the common mosquito born acute febrile illness of major health concern in India due to varying presentations from simple febrile illness to dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The aim of the study: The present study was done to find out the presence of varying clinical features and severity with outcome during the clinical course in a tertiary care center in Tamil Nadu. Materials and methods: The present study was done as a prospective observational study at government Omandurar Medical College, Chennai/ Kasturba Gandhi Hospital for Women and Children in Tamil Nadu. The study was done during the period of July 2018 to December 2018 for 6 months. Patient included were more than 12 years of age. All patients were hospitalized as in patients under the medicine department. Results: 50 patients diagnosed as dengue positive through dengue IgM Elisa method were taken for the study. The common clinical feature was fever high grade with chills, followed by headache, followed by myalgia, followed by nausea and vomiting followed by rash and GI bleeding. The commonest hematological abnormality was thrombocytopenia with leukopenia when there was a decrease in platelet count less than 50000 there was leukopenia less 3000 which improved with the recovery of rising platelet count. USG showed third space fluid accumulation due to plasma leakage P. Malarvizhi, Gananasambandam Usha. A study of clinical manifestations of dengue fever with laboratory investigations and outcome in a tertiary care center in Tamil Nadu. IAIM, 2019; 6(3): 95-98. Page 96 as evident by GB wall edema (associated with severe dengue) and right pleural effusion, followed by minimal ascites. Elevation of liver enzymes was noted in a few patients in our study. Severe thrombocytopenia was associated with gum bleeding in the younger age group. Melena was present in patients more than 20 years of age group. Menorrhagia was noted in female patients with thrombocytopenia. Few patients with GI bleed and severe thrombocytopenia required platelet transfusion. No mortality was observed and all patients recovered fully. Conclusion: Dengue is a common mosquito-borne viral illness of urban areas. Early hospitalization with appropriate clinical evaluation, relevant investigations, and appropriate management under medical supervision improves the clinical outcome of dengue positive patients hospitalized. Early referral of the patient with hospitalization improves the clinical outcome and reduces mortality.